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The conclusion I have to come to is it would appear that perhaps one of the many Win 10 OS updates may have lead to this failure and Samsung do not appear to have addressed it by releasing an updated driver. The SE-506 used to work with BDs a few months ago. My SE-506 only gets used infrequently it was purchased to enable watching of BD and DVD discs when on the go. Oh and yes, I have tried different BD discs which I know to be working on other devices (including a built-in BD drive in one of the devices, confirming that it's not the CyberLink PowerDVD software, if there was any doubt there). scs.exe reported no problems found and the Win 10 troubleshooter just repeatedly says the device needs to be rebooted (I'm only prepared to reboot so many times.). I have also run scs.exe and the Win 10 troubleshooter. I have tried using the manufacturer's supplied single cable and a split cable.
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#Samsung portable dvd writer application not found pro
I have tried the SE-506 on three different computers with three different Win 10 builds (Pro 1703, Home 1703 and Pro 1607). I am able to play DVD discs but once a BD disc is placed in the drive it spends ages not recognising the disc and then reports the drive empty to the OS (Win 10). My Samsung SE-506 /TSSTcorp BDDVDW SE-506CB USB BD/CD/DVD writer is also suffering from this issue.